Basal Body Components Exhibit Differential Protein Dynamics during Nascent Basal Body Assembly
نویسندگان
چکیده
منابع مشابه
Basal body components exhibit differential protein dynamics during nascent basal body assembly.
Basal bodies organize cilia that are responsible for both mechanical beating and sensation. Nascent basal body assembly follows a series of well characterized morphological events; however, the proteins and their assembly dynamics for new basal body formation and function are not well understood. High-resolution light and electron microscopy studies were performed in Tetrahymena thermophila to ...
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Basal bodies organize the nine doublet microtubules found in cilia. Cilia are required for a variety of cellular functions, including motility and sensing stimuli. Understanding this biochemically complex organelle requires an inventory of the molecular components and the contribution each makes to the overall structure. We define a basal body proteome and determine the specific localization of...
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Singlet microtubules and structures that have the morphology and dimensions of the basal body cartwheel complex self-assemble in extracts derived from Tetrahymena basal bodies.
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ggregation of ␥-tubulin, pericentrin, and myosin II (GPM) precedes de novo basal body assembly, according to a report from Kim et al. on page 719. The number of basal bodies formed is controlled by the duration of ␥-tubulin phosphorylation. Until now, it has not been clear whether basal body and centriole formation occurred before or after clouds of pericentriolar material take shape. To answer...
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The basal body shares similar architecture with centrioles in animals and is involved in nucleating flagellar axonemal microtubules in flagellated eukaryotes. The early-branching Trypanosoma brucei possesses a motile flagellum nucleated from the basal body that consists of a mature basal body and an adjacent pro-basal body. Little is known about the basal body proteome and its roles in basal bo...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2009
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e08-08-0835